We are entering the final games of the first third of the NFL season. Believe that statement or not, the season is, as always, zooming by. Another week has gone by and this one was filled with surprises, letdowns and, of course, the injury plague continuing.
But fear not! It’s Week 6, and it’s time to look closely at the data gathered from the five weeks of games. That should help make it easier to pick players for DFS and hopefully more accurate, as long as they stick to their trends. So, let’s not waste any more time and start building that winning DFS lineup for Week 6!
Week 6 NFL “FastDraft Flex Six Frenzy” Lineup Advice (2025) | NFL DFS Picks
Ashton Jeanty (RB, Las Vegas Raiders)
Sitting as the current RB12 in fantasy football, rookie Ashton Jeanty has been good this season. The problem is, he hasn’t repaid people for drafting him in the first round. That being said, we should get another taste of why Jeanty was rated so high coming into this season. He’s only finished inside the RB10 once this season, but it just so happens he was the RB1. Quarterback for the Las Vegas Raiders, Geno Smith has been pretty close to awful so far, and they’re going to need the rookie running back to take some pressure off of him this week. The Raiders face off against the Tennessee Titans, which should be a solid matchup at the position.
If you missed the calamity last week, the Titans should’ve been stomped by the Arizona Cardinals. But in what seems to be the routine Cardinals way, due to bonehead plays, the Titans won. For most of the game, the Cardinals were running all over the Titans. Three different Cardinals scored on the ground, and it should’ve been four, but running back Emari Demercado had other plans by dropping the ball before crossing the goal line in what would’ve been a 70+ yard touchdown score. The Titans are the third-easiest defensive match-up for running backs, allowing nearly 29 points per game to the position. With the rookie getting the bulk of the workload in the backfield and Geno Smith struggling badly, this should be a top-five finish for Ashton Jeanty and a confidence boost for fantasy managers.
Josh Jacobs (RB, Green Bay Packers)
Coming off the bye week and well rested, Green Bay Packers starting running back Josh Jacobs should be ready to rock and roll this Sunday. As it stands today, Jacobs is currently the RB13 on the season, even with one fewer game in the stats. He’s finished three of his four games inside the top 18 and finished as the RB2 in his last game against the Dallas Cowboys. The backfield veteran has all the intangibles the Packers look for and has been utilized quite well. With four touchdowns in four games and averaging around 24 opportunities per game, he’s one of the most consistent running backs in fantasy football and DFS.
But the reason he’s a juicy play this week is all about the matchup on Sunday. The Green Bay Packers square off against the Cincinnati Bengals, who are dead last in nearly every metric against fantasy running backs. They’re allowing a staggering 30.7 fantasy points per game and running backs are scoring nearly seven points over their expectation. The simple fact is that the Bengals are awful and the Packers will most likely have a large lead. That means the game script will most likely include salting the game away with Josh Jacobs. He’s a smash play this week and could also very well finish inside the top five.
Davante Adams (WR, Los Angeles Rams)
The obvious name to pick would’ve been Davante Adams‘ counterpart, Puka Nacua. But the truth is, he’s going to be selected within the first couple of picks if you’re playing FastDraft’s Flex Six Frenzy. Even in other DFS formats, though, I still prefer Adams for the price tag. With the season going the way it has been for the Rams, both wide receivers are in for top-notch seasons. Even with Nacua on pace for a record season, Adams is still the WR14. A lot of that has to do with him getting into the endzone three out of the five games and averaging 71 yards per game. Those are numbers many teams’ WR1s dream of, and he’s the Rams’ WR2. The point is, Adams is going to get his, even if Nacua continues to go off.
Looking at the matchup, the Rams head to Baltimore to take on the shell of what once was the Ravens. It just keeps happening; they’re getting destroyed week after week by receivers. The Ravens are the clear-cut team to target so far this season in fantasy football and DFS. After five weeks, they’re allowing a tantalizing 36.7 points per game to the wide receiver position. If you’re not lucky enough to draft Puka Nacua in the first few picks on FastDraft or you don’t want to pay the hefty price, then taking Davante Adams is one of the best consolation prizes you can have in Week 6.
Calvin Ridley (WR, Tennessee Titans)
This is in no way, shape or form a love letter or endorsement of quarterback Cam Ward. I don’t think that Ward is playing good football at all, and I think he has a long way to go. However, that has nothing to do with the talent of wide receiver Calvin Ridley and his ability to both take the top off the defense and get peppered with targets. That’s what happened last game when the Titans came back against the Arizona Cardinals. Ridley finished that game with five catches for 131 yards. He failed to get a touchdown, but the five-for-131 is dynamite. Last week was by far his best performance, finishing as the WR11, but I think there might be an opportunity to repeat this week.
The Las Vegas Raiders are the only reason why I think Ridley will have a repeat performance. The Raiders have been very generous to wide receivers so far this season and are in the bottom ten when it comes to stopping the position. Receivers are currently scoring on average 33.5 points per game against the Raiders’ secondary. If Cam Ward can use the comeback win against the Cardinals to snap out of his rookie funk, he will hopefully continue to target his veteran receiver early and often. I will take Calvin Ridley’s talent over any Raiders secondary defender on 50/50 balls, no question. He’s proved in his career that he can get open, and he’s willing to do what it takes to come down with the catch. In general, I could see this being a sneaky good DFS/fantasy football match-up and producing some high-scoring players.
Tyler Warren (TE, Indianapolis Colts)
The rookie season for Tyler Warren keeps on rolling, and he keeps dealing. The athletic tight end finally found the endzone through the air this past week and I think that will become a trend that could continue this week. Warren has only finished outside the top ten twice and outside the top 20 once through five weeks. What’s really impressive, though, is his average of six targets per game. With 31 targets so far, he only trails Jake Ferguson, Trey McBride and Juwan Johnson amongst the tight ends. He is a steady and favorite target for quarterback Daniel Jones and will continue to be just that.
This week, the Colts face off against the Arizona Cardinals, who are in the bottom 12 against the tight end position. It’s not a perfect match-up, but being that bad against the position should only boost the talented rookie. You should be able to lock in Tyler Warren this week for another great game, and there is a high probability that he again finds the end zone.
Hunter Henry (TE, New England Patriots)
The New England Patriots’ starting tight end, Hunter Henry, makes another appearance on this list for the season. I honestly tried not to include him this week, but he’s been consistent, and what he’s showing on the field with quarterback Drake Maye is hard to ignore. Henry is averaging around six targets, three catches and 50 yards per game through five weeks. It’s not flashy by any means, but he is just always there to catch the ball. In good match-ups, Henry has finished inside the top ten twice and as the TE1 overall once.
That brings me to the main point in his favor, which is who Henry and the Patriots will face. The New Orleans Saints are the seventh-easiest matchup for fantasy tight ends. They’re generously allowing tight ends to score about 13 points per game, and that is something I expect Drake Maye to exploit. Hunter Henry goes off against poor defenses. If he can lock in facing a porous Saints defense, it could be yet another top ten finish for the big tight end.
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*Photo Credit: Jerome Miron – USA TODAY Sports*
