As we gear up for the 2025 college football season, the ACC is once again flush with storylines, quarterback changes, coaching shifts and eye-catching futures odds. The odds offer intriguing insights into where the money is moving and how each program is viewed heading into the fall.
Here’s a comprehensive look at all 17 ACC programs, including the smart bets, the long shots and everything in between.
(Odds courtesy of FanDuel Sportsbook)
Related: Post-Spring Scamp 2025 College Football Power Rankings
2025 ACC Conference Odds, Picks & Predictions
Clemson Tigers (+120)
Clemson enters 2025 as the deserved favorites. Dabo Swinney has a loaded roster that blends veteran talent with youthful explosiveness. Quarterback Cade Klubnik took a significant step forward in 2024 and now eyes a Heisman campaign and a possible first-round NFL selection. The receiving corps is deep and dangerous. The Tigers return 65% of their 2024 receiving yards, led by breakout stars Bryant Wesco Jr. and T.J. Moore. Expect Antonio Williams to continue his strong production while a healthy Tyler Brown adds another dimension. The only concern lies with the running back room, as Phil Mafah is off to the Cowboys. Gideon Davidson, a true freshman, could explode onto the scene and the intriguing conversion of Adam Randall from wide receiver to running back adds depth.
On defense, expect destruction. T.J. Parker and Peter Woods are future top-ten NFL Draft picks and Avieon Terrell locks down the backend. It’s a stacked, experienced and hungry group.
Smart Bet: Clemson to win the ACC. National Title futures might offer better value depending on the number.
Related: Early 2025 Heisman Trophy Odds, Picks & Predictions
Miami Hurricanes (+390)
Miami is coming off its best season under Mario Cristobal and they’re reloaded. Losing Cam Ward, the 2024 first overall NFL Draft pick, would topple most programs. But Carson Beck steps in from Georgia, bringing experience and pedigree, and if he’s healthy, he’s a high-level QB1. The pass-catching room was gutted — the top six options are gone — but Joshisa Trader is expected to make a leap and transfer reinforcements have arrived. The offensive line is elite on the right side with Francisco Mauigoa, Anez Cooper and James Brockermeyer forming a physical wall.
Defensively, Rueben Bain Jr. is the name to watch. A dominant pass rusher and top-ten draft prospect, he’s joined by Wisconsin transfer Xavier Lucas, strengthening a defense that should be nasty.
Betting Note: This team has playoff potential but needs offensive chemistry. Consider them a value play if you believe in Beck’s health.
Related: Ranking the 2026 College Football Quarterbacks Using “The Bill Parcells Rules”
SMU Mustangs (+800)
SMU shocked the ACC in its inaugural year and nearly won the conference. They lose key weapons like running back Brashard Smith and most of their receiving corps, but Kevin Jennings proved he could command the offense after taking over for Preston Stone.
The Mustangs’ real strength? Defense. It was the best unit in the ACC last year and returns key veterans. They’ll contend again only if their offense maintains efficiency and avoids growing pains.
Caution: Tough road stretch midseason. Circle their trip to Clemson.
Louisville Cardinals (+800)
Jeff Brohm has a team capable of winning the league. USC transfer Miller Moss will run the show offensively, while Isaac Brown, a freshman phenom, returns after rushing for over 1,100 yards.
They’re explosive, deep and aggressive. The key will be the secondary, which struggled with consistency last season. If that unit improves, this is a legitimate title contender.
Tip: This could be a high-upside wager with room to outperform odds. Track early defensive stats.
Georgia Tech Yellow Jackets (+1300)
With no Miami or Florida State, and no SMU or Louisville either, Georgia Tech’s 2025 schedule is a gift. Haynes King continues his progression at quarterback and though Eric Singleton Jr. left, Eric Rivers (Florida International) and Malik Rutherford can get it done. Penn transfer Malachi Hosley adds depth at running back.
A Week 1 win at Colorado could set the tone. The over/under of 7.5 wins is appealing and the over looks sharp.
Play: Over 7.5 wins. Conference title odds are long for a reason but don’t rule out a surprise run.
Florida State Seminoles (+2900)
A shocking 2–10 campaign led to sweeping changes. New offensive and defensive coordinators plus transfer quarterback Thomas Castellanos from Boston College take the reins. Transfers Duce Robinson and Squirrel White should help the wide receiver group and Roydell Williams and Gavin Sawchuk will form a capable backfield.
The problem? Chemistry, time and a brutal schedule that includes Alabama, Clemson and Florida.
Verdict: These odds are a trap. I would stay away from their ACC futures and if improvement comes, target mid-season overs.
Duke Blue Devils (+3100)
Four seasons with eight or more wins in the last seven years are no fluke. Manny Diaz returns as head coach and Tulane transfer Darian Mensah takes over at QB.
Strong protection, aggressive defense led by Wesley Williams and an experienced backfield give Duke a solid foundation.
Upset Alert: Hosting Illinois early could springboard a strong season.
Virginia Tech Hokies (+3400)
Despite returning quarterback Kyron Drones, the Hokies face major questions. Both coordinator spots are new, the offensive line is rebuilt and key departures hurt both sides of the ball.
Conclusion: This is a transition year. Fade futures. Watch the win total.
Pitt Panthers (+3900)
Last year, they started 7-0 and finished 0-6; a classic tale of two halves. This year, Eli Holstein returns at quarterback with legitimate upside and running back Desmond Reid might be the best fantasy football back in the country.
The defense remains stingy up front. If the secondary improves, this is a bowl team again.
Bet: Pitt making a bowl game. Avoid title futures.
Related: Devy Dart Throw: Pittsburgh QB Eli Holstein (2025)
North Carolina Tar Heels (+4100)
The most fascinating storyline of 2025 is Bill Belichick in Chapel Hill. He’ll co-coordinate the defense with son Steve and hand the offense to Freddie Kitchens. Quarterback Gio Lopez (South Alabama) is dynamic but wide receiver depth is a concern.
Defensively, transfers like Thaddeus Dixon and Pryce Yates need to hit early.
Lean: There are too many unknowns to bet now. Revisit after the first 2–3 games.
NC State Wolfpack (+4300)
After quarterback Grayson McCall retired, NC State turned to freshman C.J. Bailey, who showed promise. Offensive coordinator Kurt Roper takes over but losing star wide receiver Kevin Concepcion hurts. Offensive line questions abound and it feels like a rebuilding year.
Advice: Avoid futures. Watch for in-season ATS spots if Bailey matures.
Syracuse Orange (+6000)
Fran Brown’s first year was a magical ride. Now, Rickie Collins replaces Kyle McCord and the wide receiver corps is decimated. Johntay Cook II is a wildcard talent and running back Yasin Willis will get his shot, but the loss of firepower likely brings regression.
Play: Fade futures and bet the under on win total (if set at seven-plus).
Boston College Eagles (+6500)
Consistent albeit unspectacular, Bill O’Brien’s team will aim to overachieve again. Quarterback Grayson James or Dylan Lonergan will lead and running backs Jordan McDonald and Turbo Richard step up.
The big problem is not having a pass rush, especially after Donovan Ezeiruaku entered to the NFL and horrific red zone play in 2024.
Fade: ACC title shot unlikely. Take the OVER if the win total is sub-six.
California Golden Bears (+8500)
Star players Jaydn Ott and Fernando Mendoza are gone, but Devin Brown and freshman Jaron-Keawe Sagapolutele offer promise.
The defense was underrated last season and adds pieces in the secondary via the portal.
Betting Watch: Over 4.5 wins would be a play with their soft schedule.
Virginia Cavaliers (+9000)
The offense was bad in 2024 and now, top wide receiver Malachi Fields is gone. Transfer quarterback Chandler Morris is decent, but offensive line issues persist.
The defense can’t stop anyone. The only bright spot? A solid linebacking corps led by Kam Robinson.
Play: UNDER six wins if that’s the number.
Wake Forest Demon Deacons (+24000)
Jake Dickert arrives and inherits running back Demond Claiborne, who is quietly elite. A quarterback battle between Robby Ashford and Deshawn Purdie will be worth watching.
That being said, the pass defense was the worst in the ACC and returns most of the same players.
Angle: They’re great in CFF but not good enough to win.
Stanford Cardinals (+30000)
A coaching mess, a quarterback competition and a gutted wide receiver room. Star receiver Elic Ayomanor and quarterback Ashton Daniels are gone.
Even with a soft schedule, this program is in disarray. General Manager Andrew Luck is searching for answers.
Verdict: Avoid like the plague. Cap them at three wins.
Final Thoughts
The ACC in 2025 is Clemson’s to lose and it’s hard to bet against them. Miami and Louisville are strong challengers and SMU continues to impress. Beyond that, plenty of programs are either rebuilding or hoping to survive.
Best Bets:
- Clemson: Win the ACC (+120)
- Georgia Tech: Over 7.5 wins
- Louisville: Make the ACC Title Game (plus odds)
- Virginia: Under win total (if six or higher)
College football always delivers surprises, but with the transfer portal and coaching shifts flying, expect chaos and opportunity in equal measure.
Thanks for reading my article on “2025 ACC Conference Preview + Championship Odds, Picks & Predictions”! For more Devy and College Fantasy Football content, follow me on Twitter/X @PoshplaysFF.
